G6PC1 — Glucose-6-phosphatase catalytic subunit 1
G6PC1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
G6PC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush-border Nutrient Uptake Absorption | AMN, CPO, CUBN, DPEP1, NAAA, SLC13A1, TRPM6 | View in SCUBA |
About the gene
| Synonyms | G6PC, G6PT, GSD1a |
|---|---|
| Chromosome | 17: 42900797-42914438 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Gluconeogenesis |
Function
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.