AMN — Amnion associated transmembrane protein
AMN belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AMN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush-border Nutrient Uptake Absorption | CPO, CUBN, DPEP1, G6PC1, NAAA, SLC13A1, TRPM6 | View in SCUBA |
| Goblet cells | Epithelial Maturation Epithelial development | BAG1, CDC42EP5, CST3, KRT10, NTRK2, NXPE4, PHGR1, PPDPF +2 more | View in SCUBA |
About the gene
| Synonyms | amnionless |
|---|---|
| Chromosome | 14: 102922663-102933596 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Protein transport, Transport |
Function
Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.