NAAA — N-acylethanolamine acid amidase
NAAA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NAAA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush-border Nutrient Uptake Absorption | AMN, CPO, CUBN, DPEP1, G6PC1, SLC13A1, TRPM6 | View in SCUBA |
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36 +15 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Lysosomal & pahgocytosis | ABI3, CAMK1, CD300A, CHCHD10, DAPK1, FCGR3A, GNGT2, ICAM2 +5 more | View in SCUBA |
About the gene
| Synonyms | ASAHL |
|---|---|
| Chromosome | 4: 75913660-75941013 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Fatty acid metabolism, Lipid degradation, Lipid metabolism |
Function
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.