Brush-border Nutrient Uptake
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
CUBN and AMN form the cubam receptor for vitamin B12 and protein uptake. SLC13A1 is a sodium-sulfate cotransporter and TRPM6 an apical Mg2+ channel. DPEP1 and CPO are brush-border peptidases, and G6PC1 marks gluconeogenic absorptive enterocytes. This is an ileal-type/distal absorptive enterocyte brush-border program neighboring the M26 colonocyte transporter module.
Genes
AMN, CPO, CUBN, DPEP1, G6PC1, NAAA, SLC13A1, TRPM6
Most correlated modules
- Villus-tip enterocyte transport · correlation 0.94
- Colonocyte Solute Transport · correlation 0.93
- Crypt-top colonocyte · correlation 0.91
- Enterocyte lipid metabolism · correlation 0.89
- Amino acid absorption · correlation 0.89
- Mature enterocyte differentiation · correlation 0.89
- Brush-border nutrient uptake · correlation 0.88
- Long-gene Nuclear Transcripts · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.