GAB2 — GRB2 associated binding protein 2
GAB2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GAB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | MAPK Stress Kinase Inflammatory | ARHGAP26, BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1 +12 more | View in SCUBA |
| Monocytes | Endosomal Sorting Vesicular traficking | FPGS, GGA2, HGS, MAFG, PIK3R5, SEMA6B, SSH1, TPRA1 +1 more | View in SCUBA |
About the gene
| Synonyms | KIAA0571 |
|---|---|
| Chromosome | 11: 78215293-78418348 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
Function
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.