BRAF — B-Raf proto-oncogene, serine/threonine kinase
BRAF belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRAF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB signaling BCR/AP1/NFKb pathway | ARIH1, BACH1, HERPUD1, MTMR6, RAB21, RASGEF1B, REL, RNMT +5 more | View in SCUBA |
| CD4⁺ T cells | TCR early activation TCR/AP1/NFKb pathway | ARIH1, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2, JOSD1 +11 more | View in SCUBA |
| Gamma-delta T cells | MAPK Kinase Signaling TCR Signaling | ARIH1, B4GALT1, CDK16, CHD1, DYRK1A, GNA13, KDM2A, MAP3K2 +8 more | |
| Lymphatic endothelial | MAPK-ERK Signaling migration & adhesion | ARIH1, CPNE8, DENND4A, ELF2, FBXO11, FNDC3B, GRB10, NT5C2 +6 more | View in SCUBA |
| Macrophages | MAPK Stress Kinase Inflammatory | ARHGAP26, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1, FOXK2 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ABTB3, AOAH, ARID1B, ARID2, ATP8A1, ATXN1, CCSER2, CDC42SE2 +13 more | |
| Natural Killer cells | MAPK/AP-1 Signaling Inflammation | B3GNT7, FAM177A1, FOSL2, GPBP1, PDE4B, PIK3R1, RALGAPA1, SDCBP +4 more | View in SCUBA |
About the gene
| Synonyms | BRAF-1, BRAF1 |
|---|---|
| Chromosome | 7: 140719327-140924929 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Transporters |
| Molecular function | Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase |
Function
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2. May play a role in the postsynaptic responses of hippocampal neurons.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.