MAPK Stress Kinase
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
Strong kinase signaling theme: MAPK8 (JNK1), BRAF (RAF kinase), PRKCE (PKC-epsilon), SIK3 (AMPK-related kinase), MAP4K3 (Ste20/GCK kinase upstream of mTOR/MAPK), YES1 (Src-family kinase), PEAK1 (scaffold pseudokinase), and PHLPP1 (phosphatase for Akt/PKC). GAB2 scaffolds PI3K/MAPK. MRTFA links actin dynamics to SRF transcription. EIF2AK3 (PERK) adds ER stress kinase. CRY1 suggests circadian regulation. ARHGAP26 is a Rho GAP. The module is enriched in mono_mac and the dominant program is MAPK/stress kinase signaling, consistent with monocyte activation.
Genes
ARHGAP26, BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1, FOXK2, GAB2, HIVEP2, ITPKB, MAP4K3, MAPK8, MRTFA, PEAK1, PHLPP1, PRKCE, SIK3, SIPA1L3, YES1
Most correlated modules
- Ubiquitin Proteasome Regulation · correlation 0.97
- Golgi Vesicle Trafficking · correlation 0.97
- PI3K Lipid Signaling · correlation 0.96
- Transcriptional Kinase Regulation · correlation 0.94
- Rho GTPase Signaling · correlation 0.93
- Innate Immune Dampening · correlation 0.93
- Endosomal Rab Trafficking · correlation 0.93
- Chromatin Epigenetic Regulation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.