ESYT2 — Extended synaptotagmin 2
ESYT2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ESYT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | GIMAP survival Immune regulation | ABLIM1, AKT3, ANKRD13D, ARL4C, C16orf54, CA5B, COPA, CRBN +16 more | View in SCUBA |
| Gamma-delta T cells | Histone Demethylase Program DNA/chromatin regulation | BLTP3B, CHD6, KDM6A, NECAP1, PI4K2A, PSME4, RAPGEF1, RIC1 +4 more | |
| Innate lymphoid cells | AP-1 Transcriptional Activation DNA regulation & transcription | AHNAK, ALYREF, CD81, CDV3, CITED4, ETS1, GNAI2, GRK2 +28 more | View in SCUBA |
| Macrophages | MAPK Stress Kinase Inflammatory | ARHGAP26, BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, EXT1, FOXK2 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ADD1, ANKRD36, ANKRD36C, CHIC2, ERICH1, KAT6B, MDM4, PACS1 +7 more |
About the gene
| Synonyms | CHR2SYT, FAM62B, KIAA1228 |
|---|---|
| Chromosome | 7: 158730995-158830253 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Endocytosis, Lipid transport, Transport |
Function
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.