GFRA2 — GDNF family receptor alpha 2
GFRA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GFRA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
| Monocytes | Complement C1q Macrophage Innate immunity | ACP2, C1QA, C1QB, C1QC, CLIC2, DNPH1, ITGA9, NR1H3 +4 more | View in SCUBA |
About the gene
| Synonyms | GDNFRB, NTNRA, RETL2, TRNR2 |
|---|---|
| Chromosome | 8: 21690398-21812357 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Receptor |
Function
Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.