AOAH — Acyloxyacyl hydrolase
AOAH belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AOAH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAP1, ALOX5AP, CD244, CMIP, CPNE7, CRTAM, DAPK2, DOCK5 +15 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1, DGKH +20 more | |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A, FLI1 +38 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ABTB3, ARID1B, ARID2, ATP8A1, ATXN1, BRAF, CCSER2, CDC42SE2 +13 more | |
| Natural Killer cells | NK TGF-β Regulation Immune regulation | CSK, GIMAP5, NCR1, PPP1R18, PTPN6, PYCR2, SASH3, TGFBR2 +1 more | View in SCUBA |
About the gene
| Chromosome | 7: 36512941-36724549 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted secreted proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism |
Function
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.