ADGRG6 — Adhesion G protein-coupled receptor G6
ADGRG6 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRG6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | BCAT1, C3orf80, CELF2, CPE, KLF8, KLK10, LYST, PCDH19 +5 more | View in SCUBA |
| Enterocytes | Epithelial junction adhesion Migration & adhesion | CEACAM6, CTNNB1, DSG2, KTN1, NCOA7, SAMD9L, SH3GLB1, TOP1 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | HSC Quiescence Program Stemness | AVP, CCDC175, CD164, CDH7, CHRM3, EGLN3, HEMGN, HLF +7 more | |
| Macrophages | Myeloid Signaling Regulation Innate immunity | AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A, FLI1 +38 more | View in SCUBA |
About the gene
| Synonyms | FLJ14937, GPR126 |
|---|---|
| Chromosome | 6: 142301854-142446266 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Also able to couple to G(q) G proteins. Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons. Also acts as a regulator of body length and bone mass. Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.