Myeloid Signaling Regulation
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 47 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 47 genes have a known function matching the annotation |
Why this annotation
INPP5D (SHIP1) is a phosphoinositide phosphatase critical for myeloid cell signaling and inhibitory receptor pathways. NFATC2 is a transcription factor involved in macrophage activation. TRIM14 participates in innate immune signaling. SESN3 is a stress-responsive regulator of mTOR. FRMD4B and RCSD1 are cytoskeletal regulators. WLS (Wntless) is involved in Wnt secretion. The module is very weakly coherent and mixed, but INPP5D/NFATC2/TRIM14 suggest a myeloid regulatory signaling theme. Given the weak coherence and uniform expression, this is a poorly defined mixed module.
Genes
ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A, FLI1, FRMD4B, GCNT1, GFRA2, GIMAP8, GSE1, HECTD2, HRH1, INPP5D, IRAG2, KLF3, ME1, MYLIP, NBPF1, NCOA7, NFATC2, NLRP1, PDCD4, PDK4, PER3, PIK3CG, PRKACB, RCN3, RCOR3, RCSD1, RNF125, SESN3, SIGLEC11, SPOPL, ST6GAL1, STON2, TENT5A, TMT1A, TPCN1, TRIM14, TTBK2, TXNDC16, WLS, WWP1
Most correlated modules
- DNA Damage Repair · correlation 0.90
- Macrophage Migration · correlation 0.88
- Macrophage Identity · correlation 0.86
- Cytoskeletal Migration · correlation 0.84
- Resident Mac Niche · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.