CMKLR1 — Chemerin chemokine-like receptor 1
CMKLR1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CMKLR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Tissue-resident gd T Tissue residence | AKR1C3, ASCL2, BFSP1, CARNS1, CD320, CES1, CTBP2, CXCR1 +21 more | |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CPED1, DIPK2A, FAM13A, FLI1 +38 more | View in SCUBA |
| Monocytes | Tissue Macrophage Identity Tissue homeostasis | CREBL2, CSF1R, DST, EPB41L2, SCARB2, SLC46A1, SNX5 | View in SCUBA |
| Smooth muscle cells | FOXC-PRDM16 Program Development | ARHGEF10L, CARNS1, CKMT2, DUSP26, FOXC1, FOXC2, ITIH3, MYO1D +4 more | View in SCUBA |
About the gene
| Synonyms | RVER1 |
|---|---|
| Chromosome | 12: 108288044-108339317 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.