HMG20A — High mobility group 20A
HMG20A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMG20A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Interferon Stimulated Genes Inflammation | AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN +14 more |
About the gene
| Synonyms | FLJ10739, HMGX1, HMGXB1 |
|---|---|
| Chromosome | 15: 77420412-77485607 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.