Interferon Stimulated Genes
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
Multiple bona fide interferon-stimulated genes (ISGs): OAS2 (2'-5' OAS, antiviral), DDX60 (RNA helicase ISG), SAMHD1 (dNTPase/restriction factor), SP110 (nuclear body ISG), DTX3L (PARP14 partner, IFN-regulated). These are co-expressed with T cell signaling genes LCP2 (SLP-76) and HCLS1 (HS1). The ISG cluster is the dominant identifiable program; the module likely reflects tonic IFN signaling in circulating gd T cells co-expressed with their basal TCR adapter machinery.
Genes
AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN, HMG20A, HNRNPK, HSD17B4, IK, KRI1, LCP2, NCOA4, OAS2, PSD4, RNF20, SAMHD1, SERINC3, SP110, STAT2, TM9SF2
Most correlated modules
- ER Antigen Processing · correlation 0.86
- Chromatin Remodeling · correlation 0.84
- Actin Cytoskeletal Regulation · correlation 0.83
- mTOR-Exocyst Signaling · correlation 0.82
- Vesicular Trafficking · correlation 0.81
- Antiviral ISG Response · correlation 0.81
- Butyrophilin gd Activation · correlation 0.80
- ER Glycoprotein Quality Control · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.