ACSL5 — Acyl-CoA synthetase long chain family member 5
ACSL5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACSL5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Enterocyte fatty-acid catabolism Lipid metabolism | ACOX1, CYP3A5, GDA, MIA2, MUC3A, OGDH, RIOK3 | View in SCUBA |
| Gamma-delta T cells | Interferon Stimulated Genes Inflammation | AATF, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN, HMG20A +14 more | |
| Mucosal-associated invariant T cell | Vesicle Membrane Trafficking Housekeeping | AP2B1, APOBR, CAPRIN1, CAPZA1, DDX23, G3BP1, IARS1, PITPNB +6 more | |
| Pericytes | Vascular Tone Homeostasis Housekeeping | AQP1, AQP3, ASS1, DCHS1, GIT1, NPR1, RUNDC3B, TSPAN13 +1 more | View in SCUBA |
About the gene
| Synonyms | ACS2, ACS5, FACL5 |
|---|---|
| Chromosome | 10: 112374116-112428379 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins |
| Molecular function | Ligase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt- villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.