DDX60 — DExD/H-box helicase 60
DDX60 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX60's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Type I Interferon Response Inflammation | ADAR, DTX3L, IFIH1, LAP3, OAS2, ODF3B, PARP9, SLC15A3 +3 more | View in SCUBA |
| Gamma-delta T cells | Interferon Stimulated Genes Inflammation | AATF, ACSL5, ACTR10, AGL, DTX3L, HCLS1, HIF1AN, HMG20A +14 more | |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, ARID5A, CLEC7A, DTX3L, EIF2AK2, ERICH1, IFIH1 +29 more | View in SCUBA |
| Monocytes | JAK-STAT IFN Signaling Antiviral | GBP2, LAP3, PARP9, RNF213, SP110, STAT1, STAT2, TNFSF10 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, HERC5, IFI16 +18 more |
About the gene
| Synonyms | FLJ20035 |
|---|---|
| Chromosome | 4: 168216291-168318883 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, RNA-binding |
| Biological process | Antiviral defense, Immunity, Innate immunity |
Function
Positively regulates RIGI- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.