HCLS1 — Hematopoietic cell-specific Lyn substrate 1

HCLS1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HCLS1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin cytoskeleton remodeling Cytoskeletal	ACTR2, BASP1, CAPZA1, CDV3, EIF3A, FAM107B, GRB2, LIMS1 +9 more	View in SCUBA
CD4⁺ T cells	JAK-STAT Signaling Immune regulation	ARHGAP30, CELF2, DDX17, DNAJC1, GSDMD, JAK3, MBNL1, N4BP2L2 +7 more	View in SCUBA
CD8⁺ T cells	TCR Proximal Signaling TCR Signaling	CHMP2A, CSK, MAP2K2, MPG, NOP10, PRDX5, SRP14, ZNHIT1	View in SCUBA
Gamma-delta T cells	Interferon Stimulated Genes Inflammation	AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HIF1AN, HMG20A +14 more
Innate lymphoid cells	JAK-STAT Cytokine Signaling Inflammation	AASDHPPT, ARHGAP9, CHURC1, CIDEB, CSK, DCAF7, DENND2D, EDEM2 +23 more	View in SCUBA
Macrophages	TGF-beta Signaling Inflammatory	APPL1, BBX, C6orf89, CCDC50, CREB3L2, NCKAP1L, NFIC, POGK +9 more	View in SCUBA
Mucosal-associated invariant T cell	Chromatin Complex Regulation DNA/chromatin regulation	APEH, CAPZB, CCND2, CFH, CHTF8, ESYT1, GDI2, HACD4 +9 more
Natural Killer cells	NK Cytotoxic Activation Cytotoxicity	ABI3, ALOX5AP, ARHGDIB, BPGM, CD247, GNPTAB, GZMA, LAT2 +3 more	View in SCUBA

About the gene

Synonyms	CTTNL, HS1
Chromosome	3: 121631399-121660927
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins

Function

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.