HNF4A — Hepatocyte nuclear factor 4 alpha
HNF4A belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HNF4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Senescent Colonocyte Transcription Senescence & shedding | ABCC5, CFDP1, DAZAP2, GABARAPL1, GRAMD2B, INSR, IST1, MAFG +8 more | View in SCUBA |
About the gene
| Synonyms | HNF4, MODY, MODY1, NR2A1, TCF14 |
|---|---|
| Chromosome | 20: 44355699-44432845 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Receptor, Repressor |
| Biological process | Biological rhythms, Transcription, Transcription regulation |
Function
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.