Senescent Colonocyte Transcription
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 17 genes have a known function matching the annotation |
Why this annotation
Multiple genes are enriched in sen_colono: GRAMD2B (2.1x), MAX (2.0x), RELB (2.0x), UBE2A (2.2x), CFDP1 (2.6x). RELB encodes the non-canonical NF-κB subunit activated in senescence and SASP. MAX is the obligate MYC partner whose ratio to MYC shifts in senescence. HNF4A is the master colonocyte differentiation transcription factor, whose activity is altered in senescent colonocytes. GABARAPL1 (autophagy receptor, mitophagy) and MARVELD3 (tight junction protein, barrier integrity) are consistent with senescent epithelial biology. MAFG (small Maf, NRF2 partner), PDGFA (SASP growth factor), WIPF2 (actin, cell shape), and IST1 (ESCRT-III, exosome biogenesis in senescence) further support this. This module represents the transcriptional program of senescent colonocytes, complementing neighbor M73.
Genes
Most correlated modules
- Inflammatory Cytoskeletal Remodeling · correlation 0.85
- Junction Cytoskeletal Remodeling · correlation 0.83
- Cellular Senescence · correlation 0.83
- AP-1 Stress Survival · correlation 0.82
- Colonocyte Senescence · correlation 0.79
- ER Stress & Trafficking · correlation 0.76
- Actin-Motor Organization · correlation 0.76
- Ubiquitin-Proteasome System · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.