DAZAP2 — DAZ associated protein 2
DAZAP2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DAZAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Interferon-Stimulated Genes Inflammation | ALDOA, CRTAP, DDX39B, EIF4B, GDI1, GNB2, GRINA, GSTM2 +17 more | View in SCUBA |
| Macrophages | Autophagy Vesicular Trafficking Vesicular traficking | ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1 +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | Housekeeping Translation Housekeeping | ARHGDIA, ARHGEF1, CCNI, EEF2, HLA-A, HLA-B, HNRNPA1, PABPC1 +4 more | |
| Natural Killer cells | NK Cytotoxic Signaling Cytotoxicity | BCL2L11, CBLB, CRYBG1, FYN, GPATCH8, HNRNPUL1, MAPK1, RAPGEF1 +3 more | View in SCUBA |
| Pericytes | TGF-beta Negative Feedback Inflammatory | CTNND1, EMP1, KAT6A, KBTBD2, KLF7, MLKL, RCAN1, RGS3 +6 more | View in SCUBA |
About the gene
| Synonyms | KIAA0058 |
|---|---|
| Chromosome | 12: 51238724-51271362 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.