ABCC5 — ATP binding cassette subfamily C member 5
ABCC5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Erythroid Progenitor Program Erythropoietic | CTNNBL1, MINPP1, NBAS, PDCD4, PDZD8, RNF130, SLC40A1, SNX5 +3 more | |
| Macrophages | DNA Damage Repair Stress | ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9, CREBRF +27 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Tissue homeostasis | ADAP2, ARHGAP18, CD84, FRMD4B, GNPDA1, LIPA, MAF, MRC1 | View in SCUBA |
About the gene
| Synonyms | EST277145, MOAT-C, MRP5, SMRP |
|---|---|
| Chromosome | 3: 183919934-184017939 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Transport |
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.