IL24 — Interleukin 24
IL24 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL24's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Chemokine-secreting Fibroblasts Inflammatory | CA12, CCBE1, CHI3L2, CPXM2, CXCL13, CXCL5, GAS1, GPM6B +10 more | View in SCUBA |
About the gene
| Synonyms | C49A, FISP, IL-24, IL10B, mda-7, Mob-5, ST16 |
|---|---|
| Chromosome | 1: 206897443-206904139 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Apoptosis |
Function
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway- mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.