CHI3L2 — Chitinase 3 like 2
CHI3L2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHI3L2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NFkB/MAPK activation BCR/AP1/NFKb pathway | BIRC3, CCDC107, CD72, CLEC2B, DENND4A, LRRFIP1, MAP3K8, MYADM +7 more | View in SCUBA |
| Fibroblasts | Chemokine-secreting Fibroblasts Inflammatory | CA12, CCBE1, CPXM2, CXCL13, CXCL5, GAS1, GPM6B, IGFBP2 +10 more | View in SCUBA |
| Hematopoietic progenitor cells | ILC3/γδT Priming Lymphcyte development | C2CD4D, CCL1, CCR1, CD2, CD7, FGR, GPR18, IL17RE +8 more | |
| Smooth muscle cells | IFN-gamma/NF-kB Response Inflammation | ATP6V0B, CCDC71L, CFLAR, EVA1B, GBP1, GBP2, HSPA8, IL32 +11 more | View in SCUBA |
About the gene
| Synonyms | YKL-39, YKL39 |
|---|---|
| Chromosome | 1: 111200771-111243440 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase |
Function
Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.