CXCL13 — C-X-C motif chemokine ligand 13
CXCL13 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCL13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh CXCL13 program B cell help | ASCL2, C11orf96, CD8B2, CXXC5, FILIP1L, FZD3, GFOD1, GNG4 +5 more | View in SCUBA |
| CD8⁺ T cells | Tumor mediated exhaustion Exhaustion | ANXA6, GALM, HNRNPLL, IFNG, ITM2A, PDCD1, PTPN7, SARDH +3 more | View in SCUBA |
| Fibroblasts | Chemokine-secreting Fibroblasts Inflammatory | CA12, CCBE1, CHI3L2, CPXM2, CXCL5, GAS1, GPM6B, IGFBP2 +10 more | View in SCUBA |
About the gene
| Synonyms | ANGIE, ANGIE2, BCA-1, BLC, BLR1L, SCYB13 |
|---|---|
| Chromosome | 4: 77511753-77611834 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.