ILRUN — Inflammation and lipid regulator with UBA-like and NBR1-like domains
ILRUN belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ILRUN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
About the gene
| Synonyms | C6orf106, dJ391O22.4, FLJ22195 |
|---|---|
| Chromosome | 6: 34587288-34696859 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Immunity, Innate immunity |
Function
Negative regulator of innate antiviral response. Blocks IRF3- dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.