ANKRD17 — Ankyrin repeat domain 17

ANKRD17 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ANKRD17's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Transcription/RNA processing RNA processing	BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1, ELF1 +29 more	View in SCUBA
Lymphatic endothelial	Hippo-Adhesion Signaling migration & adhesion	DOCK4, FER, GPHN, PRKCE, PTPRM, STAG1, STK3, UBE2E2 +1 more	View in SCUBA
Macrophages	Rho GTPase Signaling Cytoskeletal	ABCC1, ABR, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B, ATXN1 +44 more	View in SCUBA
Mucosal-associated invariant T cell	Histone Modification DNA/chromatin regulation	ARHGEF6, ASH1L, CLTC, FAM120B, KDM4C, NRDC, PCM1, RELCH +3 more

About the gene

Synonyms	FLJ22206, GTAR, KIAA0697, MASK2, NY-BR-16
Chromosome	4: 73073376-73258798
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	RNA-binding
Biological process	Host-virus interaction, Immunity, Innate immunity

Function

Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1- mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.