ABCC1 — ATP binding cassette subfamily C member 1
ABCC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3, CBL +24 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG, FKBP5 +31 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B, ATXN1 +44 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Regulation Tissue residence | ANKRD28, ARHGEF7, CA2, CDV3, CHD7, CYTIP, IL18R1, JMY +4 more |
About the gene
| Synonyms | GS-X, MRP, MRP1 |
|---|---|
| Chromosome | 16: 15949138-16143257 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters |
| Molecular function | Hydrolase, Translocase |
| Biological process | Lipid transport, Transport |
Function
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17- beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.