ARHGAP10 — Rho GTPase activating protein 10
ARHGAP10 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, CDC37, CXXC5, FAM136A, FERMT3, FIP1L1 +26 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARID2, ATAD2B, ATP9B, ATXN1 +44 more | View in SCUBA |
About the gene
| Synonyms | FLJ20896, FLJ41791, GRAF2 |
|---|---|
| Chromosome | 4: 147732063-148072776 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.