Rho GTPase Signaling
Gene co-expression module in Macrophages
| Category | Cytoskeletal |
|---|---|
| Genes | 53 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 53 genes have a known function matching the annotation |
Why this annotation
Multiple Rho GTPase regulators are present: TRIO (Rho/Rac GEF), DOCK5 (Rac GEF), ARHGAP10 (Rho GAP), ABR (Rho GAP/GEF). USP34 (deubiquitinase) and BIRC6/UBR5 (E3 ligases) add ubiquitin regulation. MKLN1 is an actin-binding protein. MON2 and ATP9B relate to membrane/vesicle trafficking. ETV6 is a transcription factor enriched in mono_mac. The module is enriched in mono_mac and the dominant functional theme is Rho GTPase-mediated cytoskeletal and signaling regulation, consistent with monocyte migration and phagocytic activity.
Genes
ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B, ATXN1, BIRC6, CAPN7, CBLB, CREBBP, DOCK4, DOCK5, ERC1, ETV6, FAM13B, FAM193A, FNDC3A, FOXJ3, FRYL, GPATCH8, HECTD4, ILRUN, LARP4B, MKLN1, MON2, MTMR3, NF1, NFAT5, PDE7A, PPP6R3, R3HCC1L, RNF111, SIPA1L2, SLC25A13, SLCO3A1, SLMAP, SMURF1, STRN3, TBC1D12, TLK2, TRIO, TRPS1, TRRAP, UBR2, UBR5, USP32, USP34, WDR20, WDR37, ZXDC
Most correlated modules
- Ubiquitin Proteasome Regulation · correlation 0.98
- Chromatin Epigenetic Regulation · correlation 0.98
- Rho GTPase Signaling · correlation 0.97
- Endosomal Vesicle Trafficking · correlation 0.97
- Innate Immune Dampening · correlation 0.97
- Epigenetic Remodeling · correlation 0.96
- Ubiquitin-Proteasome Regulation · correlation 0.96
- Transcriptional Regulation · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.