ING4 — Inhibitor of growth family member 4
ING4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ING4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | ATIC, CD244, CYTH4, EIF2S2, GPR68, GSDMD, KEAP1, MCM3 +11 more |
About the gene
| Synonyms | my036, p29ING4 |
|---|---|
| Chromosome | 12: 6650301-6663142 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Apoptosis, Cell cycle |
Function
Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.