Mucosal-associated invariant T cell: gene co-expression modules
Semi-invariant T cells restricted by MR1, recognising bacterial riboflavin metabolites; enriched in mucosa and liver, they respond rapidly with cytotoxicity and IL-17, bridging innate and adaptive immunity.
SCUBA's reference network for Mucosal-associated invariant T cell holds 143 gene modules covering 2,318 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
Cytoskeletal (4)
- Actin Cytoskeletal Dynamics · 11 genes
- Actin Cytoskeletal Remodeling · 16 genes
- Cytoskeletal Organization · 13 genes
- Endosomal Actin Organization · 16 genes
cytotoxicity (4)
- Cytotoxic Effector · 19 genes
- Cytotoxic Lymphocyte Program · 18 genes
- IL-12 Cytotoxic Effector · 16 genes
- NK-like Cytotoxic · 12 genes
DNA/chromatin regulation (19)
- Chromatin & Splicing · 20 genes
- Chromatin Complex Regulation · 18 genes
- Chromatin Epigenetic Regulation · 23 genes
- Chromatin Epigenetic Regulation · 16 genes
- Chromatin Maintenance State · 12 genes
- Chromatin Regulation · 10 genes
- Chromatin Remodeling · 22 genes
- Chromatin Remodeling · 10 genes
- Chromatin Remodeling · 18 genes
- Circadian Transcriptional Regulation · 11 genes
- Epigenetic Chromatin Regulation · 10 genes
- Epigenetic Maintenance · 22 genes
- Histone Modification · 12 genes
- Nuclear Receptor Chromatin · 10 genes
- Polycomb Repression · 24 genes
- SWI/SNF Chromatin Remodeling · 17 genes
- SWI/SNF Chromatin Remodeling · 22 genes
- Transcription Factor Activity · 12 genes
- Transcriptional Co-regulation · 10 genes
Housekeeping (15)
- Cellular Housekeeping · 26 genes
- Cellular Housekeeping · 16 genes
- Cellular Maintenance · 13 genes
- Cyclophilin-Mediated Folding · 19 genes
- Housekeeping Translation · 13 genes
- Leukocyte Housekeeping · 14 genes
- Metabolic Homeostasis · 19 genes
- Nuclear regulatory housekeeping · 15 genes
- Nuclear-Cytoplasmic Transport · 12 genes
- Nuclear-Cytoskeletal Organization · 13 genes
- Post-translational Regulation · 17 genes
- RNA Biogenesis & Folding · 15 genes
- T cell Homeostasis · 23 genes
- Vesicle Membrane Trafficking · 15 genes
- Vesicular Trafficking · 14 genes
Immune regulation (12)
- Apoptosis Regulation · 10 genes
- BMP/TGF-β Inhibitory · 11 genes
- cAMP Immune Regulation · 9 genes
- NF-κB Activation · 12 genes
- NF-κB Immune Survival · 12 genes
- NF-κB Negative Feedback · 16 genes
- NF-κB Survival Signaling · 13 genes
- T cell Survival Regulation · 16 genes
- TCR Signal Attenuation · 17 genes
- TGF-beta Response · 30 genes
- TGF-β Immune Regulation · 17 genes
- Transcriptional Repression · 16 genes
Inflammation (10)
- IL-18 Innate Activation · 12 genes
- Immunoproteasome Activity · 13 genes
- NADPH Oxidase & Innate Immune · 18 genes
- NF-κB Activation · 17 genes
- NF-κB Effector Activation · 19 genes
- STAT3 Cytokine Signaling · 13 genes
- Type I Interferon · 27 genes
- Type I Interferon · 18 genes
- Type I Interferon · 11 genes
- Type I Interferon · 15 genes
migration & adhesion (11)
- Chemokine Receptor Migration · 15 genes
- Cytoskeletal Migration · 17 genes
- Cytoskeletal Migration · 8 genes
- Cytoskeletal Migration · 18 genes
- Cytoskeletal Remodeling Migration · 23 genes
- Integrin Actin Adhesion · 20 genes
- Lymphocyte Migration · 13 genes
- Lymphocyte Migration · 17 genes
- Lymphocyte Trafficking · 17 genes
- Mucosal MAIT Homing · 14 genes
- Rho GTPase Migration · 13 genes
Mitochondrial & OxPhos (8)
- ATP Synthase Complex · 12 genes
- Mitochondrial Biogenesis · 24 genes
- Mitochondrial Housekeeping · 16 genes
- Mitochondrial Metabolism & Redox · 16 genes
- Mitochondrial OxPhos · 14 genes
- Mitochondrial OxPhos · 12 genes
- Mitochondrial Quality Control · 8 genes
- Mitochondrial Ribosome · 31 genes
Protein processing & ER (5)
- Antigen Processing · 17 genes
- ER & Mitochondrial Assembly · 18 genes
- ER Glycosylation & Ubiquitin · 18 genes
- ER Protein Glycosylation · 12 genes
- ER Stress Response · 13 genes
RNA processing & translation (11)
- Co-transcriptional Splicing · 25 genes
- mRNA 3' Processing · 12 genes
- mRNA Decay Program · 22 genes
- mRNA Export & Processing · 15 genes
- mRNA Processing Translation · 16 genes
- NF-κB RNA Regulation · 23 genes
- RNA Processing Stress · 12 genes
- RNA Splicing m6A · 24 genes
- RNA Splicing Processing · 13 genes
- Splicing Regulation · 18 genes
- Translation Elongation · 17 genes
Stress (13)
- AP-1 Immediate Early · 26 genes
- Autophagy & Trafficking · 15 genes
- Dissociation Stress Response · 8 genes
- ER Stress UPR · 18 genes
- Heat Shock Response · 22 genes
- Heat Shock Response · 9 genes
- Hypoxia-ER Stress · 14 genes
- Innate Stress Activation · 14 genes
- Integrated Stress Response · 16 genes
- Oxidative Stress Response · 20 genes
- Oxidative Stress Response · 20 genes
- Stress Granule Response · 12 genes
- Stress-Induced Growth Arrest · 17 genes
T cell maturation (14)
- AP-1/MEF2 Activation · 17 genes
- Lymphocyte Survival · 13 genes
- MAIT Cell Identity · 25 genes
- MAIT Effector Maturation · 19 genes
- Mature Effector MAIT · 16 genes
- Naive T cell · 15 genes
- RUNX3 Tissue Identity · 19 genes
- STAT4 T cell Identity · 16 genes
- T cell Activation · 16 genes
- T cell Homeostasis · 28 genes
- T cell Homeostasis · 12 genes
- T cell Identity · 18 genes
- T cell Quiescence · 22 genes
- T cell Transcriptional Identity · 17 genes
Tc17 program (1)
- Tc17 / MAIT17 · 14 genes
TCR Signaling (11)
- Calcineurin-NFAT Signaling · 12 genes
- Calcium Signal Integration · 29 genes
- Immune Synapse Signaling · 30 genes
- PI3K MAPK Signaling · 20 genes
- PI3K-Calcineurin Signaling · 11 genes
- RAS-GEF Signaling · 11 genes
- T cell Activation Signaling · 15 genes
- T cell Surface Signaling · 8 genes
- TCR Activation Signaling · 21 genes
- TCR Signaling Identity · 19 genes
- TCR-Induced Early Response · 12 genes
Tissue residence (5)
- Anti-inflammatory Homing · 9 genes
- MAIT Tissue Residence · 16 genes
- Retinoic Acid Response · 8 genes
- Tissue Residency · 17 genes
- Tissue Residency Regulation · 13 genes