ATIC — 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATIC belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATIC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Nucleotide Metabolism Biosynthesis Mitochondrial & OxPhos | ATP5MC1, C1QBP, CCT7, DCTPP1, EBNA1BP2, EEF1E1, EIF5A, GADD45GIP1 +13 more | View in SCUBA |
| Gamma-delta T cells | Chromatin TF Regulation DNA/chromatin regulation | ALDH9A1, ARMC1, ERAP2, HDAC7, KAT8, LTN1, PHF14, PRPF6 +10 more | |
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | AHCY, ANP32A, ANTKMT, APEX1, ARL2, ATP5F1A, ATP5ME, CCDC85B +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | CD244, CYTH4, EIF2S2, GPR68, GSDMD, ING4, KEAP1, MCM3 +11 more |
About the gene
| Synonyms | AICARFT, IMPCHASE, PURH |
|---|---|
| Chromosome | 2: 215311956-215349773 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Multifunctional enzyme, Transferase |
| Biological process | Purine biosynthesis |
Function
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.