CYTH4 — Cytohesin 4
CYTH4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYTH4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell antigen presentation B cell maturation | APBB1IP, BMP2K, BTN2A2, CIITA, EVL, HHEX, MS4A1, SLC35D2 +6 more | View in SCUBA |
| Gamma-delta T cells | Antiviral ISG Response Inflammation | ACTR1A, ATRX, CD164, FGD3, GIT2, LASP1, PARP10, RGS3 +6 more | |
| Hematopoietic progenitor cells | Lymphocyte Signaling Lymphcyte development | ADGRG5, AHR, AKNA, CARD11, CORO1A, KIAA0930, LSP1, PAK1 +3 more | |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | ATIC, CD244, EIF2S2, GPR68, GSDMD, ING4, KEAP1, MCM3 +11 more | |
| Neutrophils | Bacterial Phagocytosis Program Phagocytosis | CASP4, CLEC7A, CSF2RB, CSF3R, FCGR2A, LY96, SLC11A1, SLC25A37 +1 more |
About the gene
| Synonyms | CYT4, cytohesin-4, PSCD4 |
|---|---|
| Chromosome | 22: 37282027-37315341 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.