Oxidative Stress Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
This module is heterogeneous but contains several notable functional clusters. KEAP1 (oxidative stress sensor/NRF2 regulator), ING4 (chromatin/tumor suppressor, NF-kB repressor), GSDMD (gasdermin D, pyroptosis executor), MUS81 (DNA repair endonuclease), MCM3 (DNA replication helicase), CYTH4 (ARF GEF, immune cell migration), RHOU (atypical Rho GTPase), NUP62 (nuclear pore), EIF2S2 (translation initiation), CD244 (2B4, NK/T activating receptor), GPR68 (proton-sensing GPCR, expressed during acidosis/inflammation), PFDN6 (prefoldin chaperone), WDR77 (methylosome), ATIC (purine synthesis), MGAT1 (N-glycosylation), TRAPPC12 (vesicle tethering). The coherent neighbors in this batch are a trafficking module (M88) and a mitochondrial/housekeeping module (M12), suggesting these modules share baseline expression programs. The strongest overlapping theme here is stress/immune activation sensing: KEAP1-NRF2 oxidative stress axis, GSDMD pyroptosis, GPR68 acidosis sensing, ING4 chromatin stress response. This is a mixed module but the stress-response/immune-checkpoint theme is dominant.
Genes
ATIC, CD244, CYTH4, EIF2S2, GPR68, GSDMD, ING4, KEAP1, MCM3, MEA1, MGAT1, MUS81, NUP62, PFDN6, PHYKPL, PRSS35, PTRH1, RHOU, TRAPPC12, WDR77
Most correlated modules
- Mitochondrial OxPhos · correlation 0.94
- Cellular Housekeeping · correlation 0.94
- Vesicle Membrane Trafficking · correlation 0.93
- Mitochondrial Ribosome · correlation 0.91
- Cellular Housekeeping · correlation 0.90
- Type I Interferon · correlation 0.87
- Lymphocyte Survival · correlation 0.83
- RNA Splicing Processing · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.