KCNJ13 — Potassium inwardly rectifying channel subfamily J member 13
KCNJ13 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNJ13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Xenobiotic Detoxification Nutrient metabolism | ARHGDIG, FAM151A, FMO1, GSTA2, HADH, HSD3B1, IDH1, OTC +1 more | View in SCUBA |
About the gene
| Synonyms | Kir1.4, Kir7.1, LCA16 |
|---|---|
| Chromosome | 2: 232765802-232776565 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.