HADH — Hydroxyacyl-CoA dehydrogenase
HADH belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HADH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Xenobiotic Detoxification Nutrient metabolism | ARHGDIG, FAM151A, FMO1, GSTA2, HSD3B1, IDH1, KCNJ13, OTC +1 more | View in SCUBA |
| Gamma-delta T cells | Mitotic Spindle Cell cycle | CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, DNMT1, FAM111A, GMPS +11 more | |
| Goblet cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ATP5F1B, ATP5PB, CD99, COTL1, ECHS1, GPR160, PRDX3, SUCLG1 +1 more | View in SCUBA |
| Macrophages | DNA Replication Metabolism Cell cycle | AGPAT5, CBX1, DCK, FADS1, HACD3, ICMT, IDH2, MTHFD1 +11 more | View in SCUBA |
About the gene
| Synonyms | HADH1, HADHSC, SCHAD |
|---|---|
| Chromosome | 4: 107989714-108035241 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase, Transferase |
| Biological process | Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis |
Function
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.