OTC — Ornithine transcarbamylase
OTC belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OTC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Xenobiotic Detoxification Nutrient metabolism | ARHGDIG, FAM151A, FMO1, GSTA2, HADH, HSD3B1, IDH1, KCNJ13 +1 more | View in SCUBA |
About the gene
| Synonyms | OTC1, OTCase, OTCD |
|---|---|
| Chromosome | X: 38352586-38421446 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle |
Function
Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.