Xenobiotic Detoxification
Gene co-expression module in Enterocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
The module is dominated by xenobiotic/steroid metabolism and nitrogen metabolism genes. These include GSTA2, FMO1 and HSD3B1, plus OTC (urea cycle), IDH1 (NADPH supply) and HADH (fatty acid beta-oxidation). This is a mature absorptive enterocyte metabolic signature, likely from ileal-like or proximal colonocytes. Lower detection (57%) suggests a subset-restricted differentiated state. TFEC and KCNJ13 are peripheral members.
Genes
ARHGDIG, FAM151A, FMO1, GSTA2, HADH, HSD3B1, IDH1, KCNJ13, OTC, TFEC
Most correlated modules
- Carbohydrate Digestion/Detox · correlation 0.94
- Enterocyte Ion/Nutrient Transport · correlation 0.88
- PGC1A/ERRG metabolic program · correlation 0.82
- Gluconeogenesis/fructose metabolism · correlation 0.76
- Mitochondrial Energy Metabolism · correlation 0.75
- PPARA/FXR fatty acid oxidation · correlation 0.73
- Lipid/bile acid uptake · correlation 0.71
- Respiratory Chain Subunits · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.