KCNMB4 — Potassium calcium-activated channel subfamily M regulatory beta subunit 4
KCNMB4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNMB4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLIC2 +22 more | View in SCUBA |
About the gene
| Chromosome | 12: 70366290-70434292 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted membrane proteins |
| Molecular function | Ion channel |
| Biological process | Ion transport, Transport |
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.