CLIC2 — Chloride intracellular channel 2
CLIC2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLIC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Identity Endothelial cell development | CCDC69, CLSTN3, CPD, EPB41L4A, FOXF1, FZD4, IGFBP7, KCNE4 +7 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Autophagy Regulation Immune regulation | GABARAPL1, LGMN, NFKBIB, OSER1, PRRG4, RELB, RNF114, SQSTM1 +3 more | View in SCUBA |
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLN6 +22 more | View in SCUBA |
| Monocytes | Complement C1q Macrophage Innate immunity | ACP2, C1QA, C1QB, C1QC, DNPH1, GFRA2, ITGA9, NR1H3 +4 more | View in SCUBA |
About the gene
| Synonyms | CLCNL2, XAP121 |
|---|---|
| Chromosome | X: 155276211-155334657 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Chloride channel, Ion channel, Oxidoreductase, Voltage-gated channel |
| Biological process | Ion transport, Transport |
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.