Resident Mac Niche
Gene co-expression module in Macrophages
| Category | Tissue homeostasis |
|---|---|
| Genes | 31 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 31 genes have a known function matching the annotation |
Why this annotation
Hub genes IGF1, CXCL12, CD163L1, LILRB5, and GRIP1 are enriched in res_mac (2.9x, 4.3x, 3.0x, 2.2x, 3.0x respectively). IGF1 and CXCL12 are hallmarks of tissue-resident macrophage niche signaling and tissue repair. CD163L1 is a scavenger receptor expressed by resident macrophages. LILRB5 is an inhibitory receptor on tissue macrophages. ZC3H11A and SHE also show res_mac enrichment. This module reflects a resident macrophage tissue niche/homeostatic signaling program.
Genes
AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLIC2, CLN6, CXCL12, FGL2, GIMAP5, GRIP1, GUCY1A1, IGF1, IL10RB, IL16, IVD, KCNMB4, LILRB5, MATR3, P2RY13, PDE1B, PIK3R3, POLR2J3, RAD50, RBM27, SHE, TJP2, WDR74, ZC3H11A
Most correlated modules
- Macrophage Identity · correlation 0.89
- Efferocytosis Anti-inflammatory · correlation 0.85
- Stress Response Transcription · correlation 0.80
- Myeloid Signaling Regulation · correlation 0.80
- Antimicrobial Oxidative Defense · correlation 0.77
- NF-κB Effector Response · correlation 0.75
- Resident Mac Identity · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.