CHN2 — Chimerin 2
CHN2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Metabolic Housekeeping Housekeeping | ACAP1, ANTKMT, ATP6V0E2, B3GAT3, CCDC57, CMTM3, DCTD, DGUOK +12 more | |
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CLEC4F, CLIC2, CLN6 +22 more | View in SCUBA |
About the gene
| Synonyms | ARHGAP3, RhoGAP3 |
|---|---|
| Chromosome | 7: 29146547-29514328 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low- grade to high-grade tumors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.