KLK1 — Kallikrein 1
KLK1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4+ Lipid Metabolism Nutrient processing | AKAP7, ARSD, CCND1, DAPL1, EMC10, GALK1, GHR, LPCAT2 +18 more | View in SCUBA |
About the gene
| Synonyms | Klk6 |
|---|---|
| Chromosome | 19: 50819146-50823787 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
Function
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva; Neisseria is an obligate commensal of the nasopharyngeal mucosa
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.