AKAP7 — A-kinase anchoring protein 7
AKAP7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKAP7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proliferation/differentiation Cell cycle | AIG1, CCND1, DTX1, KLF4, SUSD4, TLR5, ZNF827 | View in SCUBA |
| Fibroblasts | Adventitial Fibroblast State Developmental | BLNK, C1QA, CACNA1G, CALCRL, COL21A1, CYP1B1, FAT3, KIRREL2 +9 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | ARID1A, CEP57, EIF4E, ENOSF1, GGNBP2, HERC5, HNRNPD, KTN1 +8 more |
About the gene
| Synonyms | AKAP15, AKAP18 |
|---|---|
| Chromosome | 6: 131135467-131283535 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.