CCND1 — Cyclin D1
CCND1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCND1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proliferation/differentiation Cell cycle | AIG1, AKAP7, DTX1, KLF4, SUSD4, TLR5, ZNF827 | View in SCUBA |
| Endothelial | VEGF Tip Cell Signaling Endothelial cell development | ADAMTS5, BDKRB2, CA2, CBLB, DGKD, ESM1, GABRD, GNAI1 +7 more | View in SCUBA |
| Fibroblasts | CYGB+ Quiescent Fibroblast Housekeeping | CYGB, FARP1, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1, PDK4 +5 more | View in SCUBA |
| Lymphatic endothelial | ECM Remodeling TGFb migration & adhesion | CCDC80, CHRDL1, CRIP1, CTSH, ECSCR, HS3ST1, IARS2, LAMB2 +8 more | View in SCUBA |
| Macrophages | Resident Mac Identity Tissue homeostasis | ACVRL1, CD200R1, CFD, CR1, CTSF, EMB, EPHX1, F13A1 +16 more | View in SCUBA |
| Pericytes | Actin Dynamics Cytoskeletal | ARPC1A, DSTN, EMP3, MGST3, NDUFA4, PTP4A3, S100A6 | View in SCUBA |
| Smooth muscle cells | Pericyte Signature Development | AC100803.3, COX4I2, CPM, ENTPD3, GPR20, GPRIN3, GRIP2, ISYNA1 +8 more | View in SCUBA |
About the gene
| Synonyms | BCL1, D11S287E, PRAD1, U21B31 |
|---|---|
| Chromosome | 11: 69641156-69654474 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Transporters |
| Molecular function | Cyclin, Repressor |
| Biological process | Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation |
Function
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.