EMC10 — ER membrane protein complex subunit 10
EMC10 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EMC10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Protein Biogenesis Protein processing & ER | AUP1, BAZ1B, DNAJC1, EML3, FAM32A, FRG1, GLUD1, KLC1 +10 more | |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | BPNT2, CALU, CLPTM1L, CTSB, DHRS7, GBA1, GNS, GPNMB +21 more | View in SCUBA |
About the gene
| Synonyms | C19orf63, HSM1, HSS1, INM02 |
|---|---|
| Chromosome | 19: 50476400-50490871 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Biological process | Angiogenesis |
Function
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N- terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.