BEST4+ Lipid Metabolism
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
This module is enriched in BEST4+ colonocytes and contains a mixed set of genes. CCND1 (cyclin D1, G1 cell cycle/proliferation), SLC27A3 (fatty acid transporter), MANBA (lysosomal beta-mannosidase), SLC12A9 (cation-chloride cotransporter), GALK1 (galactokinase, galactose metabolism), NECTIN1 (cell adhesion), LPCAT2 (lysophosphatidylcholine acyltransferase, lipid metabolism), PROS1 (protein S, anticoagulant), GHR (growth hormone receptor), RBM38 (RNA-binding protein, p53 target), SMPDL3B (sphingomyelin phosphodiesterase), RNASE6 (antimicrobial RNase). The BEST4 enrichment and metabolic gene content suggest this is a BEST4+ colonocyte metabolic/lipid handling module. The coherence is 'strong' rather than core, reflecting some heterogeneity. Given the neighbor context (M1 is canonical BEST4 identity), this likely represents a metabolic specialization of BEST4+ cells.
Genes
Most correlated modules
- BEST4+ Survival Signaling · correlation 0.86
- BEST4+ Colonocyte Identity · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.