LTB4R — Leukotriene B4 receptor
LTB4R belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LTB4R's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ABHD15, ALDOC, ARL2BP, C20orf204, CCL20, CPNE7, EIPR1, ERG28 +21 more | View in SCUBA |
| Monocytes | Myeloid Activation Innate immunity | CCDC88B, GAS7, IL17RA, ITGAM, PRAM1, PSTPIP1, TMEM91 | View in SCUBA |
About the gene
| Synonyms | BLTR, CMKRL1, GPR16, LTB4R1, P2RY7, P2Y7 |
|---|---|
| Chromosome | 14: 24311450-24318036 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, G-protein coupled receptors, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.