ILC1 Inflammatory Activation
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
The module contains several inflammatory mediator genes: CCL20 (chemokine recruiting CCR6+ cells), LTB4R (leukotriene B4 receptor, neutrophil/NK chemoattractant signaling), IL17RE (IL-17 receptor), TGM2 (transglutaminase 2, inflammatory crosslinking), and JAML (junction adhesion molecule-like, activating receptor on NK/ILC). ALDOC (glycolysis) is highly enriched in ILC1 (6.1x). TRAC (T-cell receptor alpha constant) is a notable T-cell contamination signal but most genes are ILC1-enriched. The module is enriched in ILC1 cells and likely reflects an inflammatory activation state of ILC1s with lipid mediator and chemokine signaling. As a neighbor of M17, these two modules may co-activate in ILC1s under inflammatory conditions.
Genes
ABHD15, ALDOC, ARL2BP, C20orf204, CCL20, CPNE7, EIPR1, ERG28, ERGIC2, FARS2, GPR82, GRN, GSDMD, IL17RE, INPP4A, JAML, LTB4R, MTIF3, NECTIN2, NMRK1, PMVK, REEP3, REPIN1, RGS9, RNF146, SREK1IP1, TBC1D31, TEX30, TGM2, TRAC
Most correlated modules
- Mitochondrial Metabolism · correlation 0.93
- ILC-1 identity · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.